{"id":531,"date":"2020-12-06T14:10:11","date_gmt":"2020-12-06T14:10:11","guid":{"rendered":"http:\/\/sarahgildea.com\/blog\/?p=531"},"modified":"2020-12-06T14:11:41","modified_gmt":"2020-12-06T14:11:41","slug":"not-all-the-things-that-vitamin-c-can-do","status":"publish","type":"post","link":"https:\/\/sarahgildea.com\/blog\/not-all-the-things-that-vitamin-c-can-do\/","title":{"rendered":"Not All the Things that Vitamin C Can Do"},"content":{"rendered":"
    \n
  1. Its intermediate free radical is relatively nonreactive, especially with oxygen [nothing can interfere with its effectiveness].<\/li>\n
  2. In the gastro-intestinal tract, vitC is changed to an ionized form (was neutral, became electrically charged), called ascorbate (ASC), and its oxidized counterpart, dehydroascorbic<\/em> acid (DHA). These are absorbed through different transporter systems with an increased affinity for ASC.<\/li>\n<\/ol>\n

    DHA is reduced to ASC immediately after crossing the membrane. It is transported through 4 of the 14 glucose transporters (GLUT 1\u20134), with varying affinities and efficiencies.
    \nIonization is one of the principal ways that radiation, such as charged particles and X rays, transfers its energy to matter.<\/p>\n

    For Vitamin C and its effect on Virus and Iron, go here<\/a>.<\/p>\n

      \n
    1. \n
        \n
      1. Ascorbic acid is regenerated 2x in the body:<\/li>\n
      2. DHA is reduced to ASC. b. from the kidney, it can be sent back out into the system.<\/li>\n
      3. Regenerates vitamin E and Iron.<\/li>\n
      4. Iron.<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n

        As an antioxidant, vC\u2018s action is twofold: 1st<\/sup>, by being oxidised itself, vC regenerates already oxidised substances such as iron or copper to their active form; 2nd<\/sup>, in the process, the vitamin removes the damaging oxidising agent. In the intestines it enhances iron absorption by protecting it from oxidation<\/u>. Individuals who are taking an iron supplement will increase their iron absorption by eating foods high in vitamin C at the same time.
        \nVitamin C is a cofactor with iron during the hydroxylation of proline and lysine in the production of collagen<\/u>, making it important for tissue repair and regeneration. Vitamin C and iron deficiencies are both manifested by decreased collagen synthesis, which can result in delayed healing and capillary fragility.<\/u>         https:\/\/www.sarahgildea.com\/blog\/VitaminC\/CollagenSynthesis.pdf<\/a><\/p>\n

          \n
        1. Lysine readily combines with vitamin C, especially when concentrations of lysine in the body are high. When lysine is combined with vC, your body will convert it into another amino acid, carnitine.<\/li>\n<\/ol>\n
            \n
          1. Heart disease<\/strong><\/li>\n<\/ol>\n

            a. You can’t make collagen without vitamin C. If you don’t get enough, arteries become weak. A lesion forms, followed by the other stages of developing heart disease.
            \nAccording to Johns Hopkins, high doses of vitamin C \u2014 an average of 500 mg per day \u2014 may produce small reductions of blood pressure. Vitamin C may act as a diuretic, removing excess fluid from your body. This may help lower the pressure within your blood vessels.<\/p>\n

            b. Losartan<\/strong> is an Angiotensin<\/strong> II receptor blocker. Angiotensin is a hormone in your body that narrows your blood vessels. How does it actually do this? It creates Potassium in the body<\/strong>.
            \nMany studies have highlighted the benefits of ascorbic acid for chronic cardiovascular diseases such as hypertension in which angiotensin II (Ang II) plays a significant role. Ascorbic acid decreases the binding affinity of the AT(1) receptor<\/u>.
            \nThe binding affinity is the strength of the interaction between two molecules that bind reversibly (interact).
            \n            Source 1<\/a>.\u00a0 \u00a0 Source 2<\/a>.<\/p>\n

              \n
            1. Bones<\/strong>:<\/li>\n<\/ol>\n

              An osteoc<\/strong>last<\/u> is a type of bone cell that breaks down<\/u> bone tissue.
              \nThe osteob<\/strong>last<\/u> form new bone. This function is critical in the maintenance and repair of bones. They have a close relationship with immune cells.
              \nOsteoporosis reflects a relative enhancement<\/u> of osteoclast activity. (Source:               https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1851862\/<\/a>) Another article<\/a>.<\/p>\n

              We don\u2019t want \u201cenhancement\u201d of a breaking down activity.<\/h3>\n

              The bone is an ever-changing organ that is remodeled by the continuous activities of osteoc<\/strong>lasts and osteob<\/strong>lasts. Because osteoclasts are culprits in many diseases of systemic and local bone loss, their activity is essential for the process of bone remodeling that replaces effete, brittle bone with new.
              \nAA remarkably inhibits the precursor RAW264.7 cell proliferation at a higher concentration, and RANKL (receptor-activated nuclear factor kappaB ligand) alone is sufficient for osteoclastogenesis. This tells us that vC regulates and balances osteoc<\/strong>last and osteob<\/strong>last activity.<\/p>\n

              9. Osteoarthritis<\/strong>. https:\/\/www.sarahgildea.com\/blog\/VitaminC\/ChondrocytesAscorbicAcid.pdf<\/a><\/p>\n

                \n
              1. What Organs Demand the Most vC?<\/strong><\/li>\n<\/ol>\n

                Vitamin C is accumulated by two types of proteins: sodium-ascorbate (ASC) co-transporters (SVCTs) and hexose transporters (GLUTs), as mentioned earlier.
                \nThe GLUT-transport of DHA is competitively inhibited by glucose, e.g., excess glucose in plasma or intestine will block the receptor-binding site and, subsequently, decrease GLUT-facilitated DHA transport. This association is also seen for DHA absorption to some specific cell types, whereas in others, glucose has less o\u03c0r even no significant effect on DHA absorption.
                \nThe distribution and transport properties vary among the different GLUTs:<\/p>\n

                GLUT1 is expressed in a broad variety of cells throughout the body [48,51];
                \nGLUT2 is primarily expressed in liver, spleen and the basolateral membrane of intestinal and renal epithelial cells [50,51];
                \nGLUT3 is found particularly in the brain and in neurons [48,51] and
                \nGLUT4 in skeletal and cardiac muscle cells, as well as in adipose tissues.<\/p>\n

                vC, under normal conditions, doesn\u2019t travel by itself, but is carried to where it is needed<\/em>.<\/p>\n\n\n\n
                Organ\/Tissue\u00a0\u00a0 vC Concentration*<\/p>\n

                Pituitary Gland\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 40-50
                \nAdrenal Gland \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 30-40
                \nEye Lens\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 25-31
                \nLiver\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 10-16
                \nBrain\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 13-15
                \nPancreas\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 10-15
                \nSpleen\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 10-15
                \nKidneys\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 5-15<\/td>\n

                		Organ\/Tissue\u00a0\u00a0 vC Concentration*<\/p>\n

                Lungs\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 7
                \nSkeletal Muscle\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 3-4
                \nTestes\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 3
                \nThyroid\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 2
                \nCerebrospinal Fluid\u00a0\u00a0\u00a0 3.8
                \nPlasma\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 0.4-1
                \nSaliva\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 0.1-9.1<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

                * mg\/100 g wet tissue, mg\/100 mL fluids<\/p>\n

                https:\/\/med.libretexts.org\/Bookshelves\/Nutrition\/Book%3A_Intermediate_Nutrition_(Lindshield)\/09%3A_Antioxidant_Micronutrients\/9.03%3A_Vitamin_C\/9.3A%3A_Vitamin_C_Absorption_and_Tissue_Accumulation<\/p>\n

                The pituitary gland produces a number of hormones. Each of these hormones affects a specific part of the body (a target organ or tissue). Because the pituitary controls the function of most other endocrine glands, it is often called the master gland. Notice that for its size, it still requires the most vC.
                \nThe adrenal glands are small glands located on top of each kidney. They produce hormones that you can’t live without, including sex hormones and cortisol.
                \nWhat this demonstrates is that vC depravation during pregnancy affects the fetus development.<\/p>\n

                  \n
                1. \n
                    \n
                  1. Vitamin C and Pain https:\/\/www.sarahgildea.com\/blog\/VitaminC\/VitaminCTreratsPain.pdf<\/a>\u00a0 \u00a0Scurvy \u2013 pain is a symptom. Lower limb pain, in general. Trauma and surgery are known to significantly deplete vC.<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n
                      \n
                    1. Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders? https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5537779\/\u00a0 \u00a0 \u00a0Another article<\/a>.<\/li>\n<\/ol>\n
                        \n
                      1. AA and Morphine addiction. https:\/\/www.sarahgildea.com\/blog\/VitaminC\/vCMorphine.pdf<\/a><\/li>\n
                      2. Menstrual pain<\/li>\n
                      3. AA and weight loss. Oxidises 30% more fat during exercise.<\/li>\n
                      4. People who were doing a double treatment of chemo and vC did not have any of the chemo side effects. When they stopped taking the vC, they started getting the side effects of the chemo. And of course, side effects stopped when they resumed vC treatment. article<\/a>.<\/li>\n
                      5. Vitamin C as treatment for Cancer instead of Chemo: Link to article.<\/a>\u00a0 \u00a0 \u00a0Link to another article.<\/a>\u00a0 \u00a0\u00a0Link to another article<\/a>.<\/li>\n<\/ol>\n

                         <\/p>\n","protected":false},"excerpt":{"rendered":"

                        Its intermediate free radical is relatively nonreactive, especially with oxygen [nothing can interfere with its effectiveness]. In the gastro-intestinal tract, vitC is changed to an ionized form (was neutral, became electrically charged), called ascorbate (ASC),…<\/p>\n

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